Oligofructose as an adjunct in treatment of diabetes in NOD mice

Oligofructose as an adjunct in treatment of diabetes in NOD mice

In type 1 diabetes, restoration of normoglycemia can be achieved if the autoimmune attack on beta cells ceases and insulin requirement is met by the residual beta cells. We hypothesize that an adjunctive therapy that reduces insulin demand by increasing insulin sensitivity will improve the efficacy of an immunotherapy in reversing diabetes. We tested the gut microbiota-modulating prebiotic, oli...

Corrigendum: Oligofructose as an adjunct in treatment of diabetes in NOD mice

Treatment effect of GABA on improve type one diabetes in NOD mice

Introduction: Gama amino butyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian nervous system. The concentration of GABA and the number of GABA cell secretion decrease in diabetic patient and experimental diabetes model. The reported effects of GABA activation on insulin secretion from beta cells have been controversial. In this study we investigated if GABA administr...

Flt3-ligand treatment prevents diabetes in NOD mice.

The mechanism by which mixed chimerism reverses autoimmunity in type 1 diabetes has not been defined. NOD mice have a well-characterized defect in the production of myeloid progenitors that is believed to contribute significantly to the autoimmune process. We therefore investigated whether chimerism induces a correction of this defect. Mixed chimerism restored production of myeloid progenitors ...

Mindfulness Based Stress Reduction as an Adjunct Treatment to Diabetes

Background: Diabetes is a significant health problem currently and is linked to a variety of mental health issues. In order to adequately control this disease, patients must have good mental health status and methods of dealing with stress. Mindfulness-Based Stress Reduction (MBSR) is a technique people can use in all facets of their life for decreasing their level of mental stress. This review...